Mechanism of action of 4-hydroxyphenylpyruvate dioxygenase inhibitor herbicide on homoterm animals and humans
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Hygiene and Ecology Institute Bogomolets National Medical University, Ukraine
Institute of Rural Health in Lublin, Poland
Iwona Bojar   

Institute of Rural Health, Jaczewskiego 2, 20–090 Lublin, Poland
J Pre Clin Clin Res. 2015;9(2):145–150
It was found that the main mechanisms of action of 4-hydroxyphenylpyruvatedioxygenase inhibitors are the development of tyrosinemia and alternations in thyroid hormone level as a result of hepatic enzyme induction. The main target organs of its action are the eyes, liver and thyroid gland. It was proved that the most adequate model for extrapolation of the effects of tyrosinemia on humans are mice, because their tyrosine aminotransferase activity level is similar to that in humans.
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