RESEARCH PAPER
Helicobacter pylori and rheumatoid arthritis
 
More details
Hide details
1
The Parker Institute, Frederiksberg Hospital, Denmark
2
Frederiksberg Hospital, Department of Clinical Microbiology, Rigshospitalet, Denmark
3
Department of Pathology, Denmark
4
Department of Clinical Microbiology , Denmark
5
Deceased
6
Department of Gastroenterology, Denmark
7
Copenhagen University Library, Section for Science and Medicine, Denmark
 
J Pre Clin Clin Res. 2007;1(1):68–73
KEYWORDS
ABSTRACT
The aim of the research was to evaluate a possible relationship between Helicobacter pylori (H. pylori) and rheumatoid arthritis. The presence of and sero-prevalence of IgG antibodies to H. pylori were determined in 59 Danish rheumatoid-arthritis patients. The sero-prevalence was compared to the prevalence of controls and the background population. H. pylori in infected and uninfected patients were compared with regards to clinical and demographic characteristics, and the extent of their inflammatory disease activity. H. pylori was found in 18 patients (31%). The sero-prevalence of H. pylori was 32%, non-significant to the prevalence of controls (36%), and of the background population (26%). H. pylori /HLO positive and H. pylori /HLO negative patients were similar with regards to clinical and demographic characteristics and inflammatory disease activity. Our results did not show an aetiologic relationship between H. pylori and rheumatoid arthritis, but further studies are needed to discard the hypothesis completely.
 
REFERENCES (43)
1.
Phillips PE: Infectious agents in the pathogenesis of rheumatoid arthritis. Seminars in Arthr and Rheum 1986, 16, 1-10.
 
2.
Bacon PA, Tunn EJ: Infection and arthritis. Q J Med 1986, 61(234), 897-899.
 
3.
Espinoza LR: Rheumatoid arthritis: etiopathogenetic considerations. Clin Lab Med 1986, 6(1), 27-40.
 
4.
Atkin S, Walker D, Mander M, Malcolm A, Dick WC: Observations on the causes of rheumatoid arthritis. Br J Rheumatol 1988, 27 (Suppl. 2), 173-175.
 
5.
Phillips PE: Evidence implicating infectious agents in rheumatoid arthritis and juvenile rheumatoid arthritis. Clin and Experim Rheum 1988, 6, 87-94.
 
6.
Rodriguez MA, Williams RC: Infection and rheumatic diseases. Clin Exp Rheumatol 1989, 7(1), 91-97.
 
7.
Wilder RL, Crofford LJ: Do infectious agents cause rheumatoid arthritis? Clin Orthop 1991, 265, 36-41.
 
8.
Inman RD: Infectious etiology of rheumatoid arthritis. Rheum Dis Clin North Am 1991, 17(4), 859-870.
 
9.
Burmester GR: Hit and run or permanent hit? Is there evidence for a microbiological cause of rheumatoid arthritis? J Rheumatol 1991, 18(10), 1443-1447.
 
10.
Ford DK: The microbiological causes of rheumatoid arthritis. J Rheumatol 1991, 18(10), 1441-1442.
 
11.
Rook GA, Stanford JL: Slow bacterial infections or autoimmunity? Immunol Today 1992, 13(5), 160-164.
 
12.
Rook GA, Lydyard PM, Stanford JL. A reappraisal of the evidence that rheumatoid arthritis and several other idiopathic diseases are slow bacterial infections. Ann Rheum Dis 1993, 52 (Suppl.1), 30-38.
 
13.
Gaston JS: The role of infection in inflammatory arthritis. QJM 1994, 87(11), 647-651.
 
14.
Greenstein AJ, Janowitz HD, Sachar DB: The extra-intestinal complications of Crohn's disease and ulcerative colitis: A study of 700 patients. Medicine (Baltimore) 1976, 55(5), 401-412.
 
15.
Hazenberg MP, Klasen IS, Kool J, Ruseler-van Embden JG, Severijnen AJ: Are intestinal bacteria involved in the etiology of rheumatoid arthritis? Review article. APMIS 1992, 100(1), 1-9.
 
16.
Granfors K, Jalkanen S, von Essen R, Lahesmaa-Rantala R, Isomaki O, Pekkola-Heino K et al.: Yersinia antigens in synovial-fluid cells from patients with reactive arthritis. N Engl J Med 1989, 320(4), 216-221.
 
17.
Granfors K, Jalkanen S, Lindberg AA, Maki-Ikola O, von Essen R, Lahesmaa-Rantala R et al.: Salmonella lipopolysaccharide in synovial cells from patients with reactive arthritis. Lancet 1990, 335(8691), 685-688.
 
18.
Granfors K, Jalkanen S, Toivanen P, Koski J, Lindberg AA.: Bacterial lipopolysaccharide in synovial fluid cells in Shigella triggered reactive arthritis. J Rheumatol 1992, 19(3), 500.
 
19.
Toivanen A: Infection and arthritis. Ann Med 1994, 26(4), 245-248.
 
20.
Midtvedt T: Intestinal bacteria and rheumatic disease. Scand J Rheumatol 1987, 64, 49-54.
 
21.
Warren JR, Marshall BJ: Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1983, 1, 1273.
 
22.
Blaser MJ: Helicobacter pylori and the pathogenesis of gastroduodenal inflammation. J Infect Dis 1990, 161(4), 626-633.
 
23.
Axon AT: Treatment of Helicobacter pylori: An overview. Aliment Pharmacol Ther 2000, 14 (Suppl 3), 1-6.
 
24.
Andersen LP, Nielsen H: Peptic ulcer: an infectious disease? Ann Med 1993, 25(6), 563-568.
 
25.
Malone DE, McCormick PA, Daly L, Jones B, Long A, Bresnihan B et al.: Peptic ulcer in rheumatoid arthritis-intrinsic or related to drug therapy? Br J Rheumatol 1986, 25(4), 342-344.
 
26.
Janssen M, Dijkmans BA, Lamers CB: Upper gastrointestinal manifestations in rheumatoid arthritis patients: Intrinsic or extrinsic pathogenesis Scan J of Gastroenterology 1990, 25 (Suppl.178), 79-84.
 
27.
Janssen M, Dijkmans BA, van der Sluys FA, et al: Upper gastrointestinal complaints and complications in chronic rheumatic patients in comparison with other chronic diseases. British J Rheumatol 1992, 31, 747-752.
 
28.
Barr M, Buckley M, O'Morain C: Review article: Non-steroidal anti-inflammatory drugs and Helicobacter pylori. Aliment Pharmacol Ther 2000, 14 (Suppl 3), 43-47.
 
29.
Showji Y, Nozawa R, Sato K, Suzuki H: Seroprevalence of Helicobacter pylori infection in patients with connective tissue diseases. Microbiol Immunol 1996, 40(7), 499-503.
 
30.
Zentilin P, Savarino V, Garnero A, Accardo S, Seriolo B: Is Helicobacter pylori infection a risk factor for disease severity in rheumatoid arthritis? Gastroenterology 1999, 116(2), 503-504.
 
31.
Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988, 31(3), 315-324.
 
32.
Price AB: The Sydney System: Histological division. J Gastroenterol Hepatol 1991, 6(3), 209-222.
 
33.
Andersen LP, Espersen F, Souckova A, Sedlackova M, Soucek A: Isolation and preliminary evaluation of a low-molecular-mass antigen preparation for improved detection of Helicobacter pylori immunoglobulin Gantibodies. Clin Diagn Lab Immunol 1995, 2(2), 156-159.
 
34.
Fries JF, Spitz P, Kraines RG, Holman HR: Measurement of patient outcome in arthritis. Arthritis Rheum 1980, 23(2), 137-145.
 
35.
Fuchs HA, Pincus T: Reduced joint counts in controlled clinical trials in rheumatoid arthritis. Arthritis Rheum 1994, 37(4), 470-475.
 
36.
Felson DT, Anderson JJ, Boers M, Bombardier C, Furst D, Goldsmith C: American College of Rheumatology. Preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheum 1995, 38(6), 727-735.
 
37.
Winchester R: The molecular basis of susceptibility to rheumatoid arthritis. Adv Immunol 1994, 56, 389-466.
 
38.
Engstrand L, Scheynius A, Pahlson C: An increased number of gamma/ delta T-cells and gastric epithelial cell expression of the groEL stressprotein homologue in Helicobacter pylori-associated chronic gastritis of the antrum. Am J Gastroenterol 1991, 86(8), 976-980.
 
39.
Braga LL, Sarosiek J, Marshal B, McCallum RW: Gold – a new potential drug for the treatment of Helicobacter pylori infection. Gastroenterology 1990, 98, A25.
 
40.
Taha AS, Sturrock RD, Russell RI: Helicobacter pylori and peptic ulcers in rheumatoid arthritis patients receiving gold, sulfasalazine, and nonsteroidal anti-inflammatory drugs. Am J Gastroenterol 1992, 87(12), 1732-1735.
 
41.
Gubbins GP, Schubert TT, Attanasio F, Lubetsky M, Perez-Perez GI, Blaser MJ: Helicobacter pylori seroprevalence in patients with rheumatoid arthritis: Effect of nonsteroidal anti-inflammatory drugs and gold compounds. Am J Med 1992, 93(4), 412-418.
 
42.
Janssen M, Dijkmans BA, Vandenbroucke JP, van Duijn W, Pena AS, Lamers CB: Decreased level of antibodies against Helicobacter pylori in patients with rheumatoid arthritis receiving intramuscular gold. Ann Rheum Dis 1992, 51(9), 1036-1038.
 
43.
Andersen LP, Rosenstock SJ, Bonnevie O, Jorgensen T: Seroprevalence of immunoglobulin G, M, and A antibodies to Helicobacter pylori in an unselected Danish population. Am J Epidemiol 1996, 143(11), 1157-1164.
 
eISSN:1898-7516
ISSN:1898-2395