REVIEW PAPER
Bioactive diet components and gastrointestinal tract health
 
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1
Department of Endoscopy, Institute of Agricultural Medicine, Lublin, Poland
2
Department of Biochemistry and Animal Physiology, Veterinary Medicine Faculty, University of Life Sciences, Lublin, Poland
3
Department of Animal Anatomy, Veterinary Medicine Faculty, University of Life Sciences, Lublin, Poland
4
Department of Cell and Organism Biology, Lund University, Lund, Sweden
CORRESPONDING AUTHOR
Rafał Filip   

Department of Endoscopy of IAM, Jaczewskiego 2, 20-090 Lublin, Poland.
 
J Pre Clin Clin Res. 2008;2(1):19–24
KEYWORDS
ABSTRACT
Some dietary components that may not be required for human existence may markedly influence the quality of life by modifying physiologic processes. These compounds can influence, in combination or alone, numerous biological functions by serving as antioxidants, immunoregulators, regulators of gene expression, modulators of several cellular processes, including growth and apoptosis. Many diseases are associated with impaired cell proliferation or differentiation and, what is most important, also with deregulations in programmed cell death, which, in the end, can lead to the promotion of the diseases such as cancer. Biologically-active molecules are capable of modifying the biochemical pathways and/or influencing specific proteins regulating apoptosis in gastrointestinal cells, which can be used for both prevention and treatment. Dietary fibres, cruciferous vegetables, flax and curcumin showed positive effect in the protection of colon cancer. Similarly, a strong inverse relationship between stomach as well as colon cancer risk and allium vegetables intake has been proved. Limonoids from citrus fruits are also considered as promising molecules with anticancer activity, such as perrillyl alcohol, which was tested in patients with advanced malignant tumours. Although the relationship between soy intake and cancer risk has not so far been clearly elucidated, it is known that isoflavones from soy may reduce the risk of estrogen-dependent breast cancer. Although functional foods of animal origin are not that well recognized, some of them, however, seem to be worthy of particular interest. Although interactions among nutrients have been inadequately examined, a few examples of negative and positive interactions exist, e.g. some components may provide beneficial effects by influencing the structure and functions of the wall as well as environment of the gastrointestinal tract, including phytohaemagglutinin (PHA) and other components, such as alpha- etoglutaric acid (AKG).
 
REFERENCES (40)
1.
Zabielski R, Le Huerou-Luron I, Guilloteau P: Development of gastrointestinal and pancreatic functions in mammalians (mainly bovine and porcine species): infl uence of age and ingested food. Reprod Nutr Dev 1999, 39(1), 5-26.
 
2.
Thompson JS, Saxena SK, Sharp JG: Regulation of intestinal regeneration: new insights. Microsc Res Tech 2000, 51(2), 129-137.
 
3.
Godlewski MM, Słupecka M, Woliński J, Skrzypek T, Skrzypek H, Motyl T, Zabielski R: Into the unknown – the death pathways in the neonatal gut epithelium. J Physiol Pharmacol 2005, 56 (Suppl 3), 7-24.
 
4.
Ciccocioppo R, Di Sabatino A, Gasbarrini G, Corazza GR: Apoptosis and gastrointestinal tract. Ital J Gastroenterol Hepatol 1999, 31(2), 162-172.
 
5.
Iwakiri R, Gotoh Y, Noda T, Sugihara H, Fujimoto K, Fuseler J, Aw TY: Programmed cell death in rat intestine: eff ect of feeding and fasting. Scand J Gastroenterol 2001, 36(1), 39-47.
 
6.
Kakimoto T, Fujise T, Shiraishi R, Kuroki T, Park JM, Ootani A, Sakata Y, Tsunada S, Iwakiri R, Fujimoto K: Indigestible material attenuated changes in apoptosis in the fasted rat jejunal mucosa. Exp Biol Med (Maywood) 2008, 233(3), 310-316.
 
7.
Fischer U, Schulze-Osthoff K: Apoptosis-based therapies and drug targets. Cell Death Diff erentiation 2005, 12, 942-961.
 
8.
Martin RM: Targeting Apoptosis with Dietary Bioactive Agents. Exp Biol Med 2006, 231, 117-129.
 
9.
Reed J: Apoptosis-regulating proteins as targets for drug discovery. Trends Mol Med 2001, 7, 314-319.
 
10.
Sun S, Hail N, Lotan R: Apoptosis as a novel target for cancer chemoprevention. J Natl Cancer Inst 2004, 96, 662-672.
 
11.
Danial N, Korsmeyer S: Cell death: critical control points. Cell 2004, 116, 205-219.
 
12.
Lockshin R, Zakeri Z: Apoptosis, autophagy, and more. Int J Biochem Cell Biol 2004, 36, 2405-2419.
 
13.
Reed J: Apoptosis mechanisms: implications for cancer drug discovery. Oncology 2004, 18, 11-20.
 
14.
Guimaraes C, Linden R: Programmed cell death: apoptosis and alternative death styles. Eur J Biochem 2004, 271, 1638-1650.
 
15.
Hail N: Mechanisms of vanilloid-induced apoptosis. Apoptosis 2003, 8, 251-262.
 
16.
Bouralexis S, Findlay D, Evdokiou A: Death to the bad guys: targeting cancer via Apo2L/TRAIL. Apoptosis 2005, 10, 35-51.
 
17.
Reed J: Dysregulation of apoptosis in cancer. J Clin Oncol 1999, 17, 2941-2953.
 
18.
Perik P, de Vries E, Gietema J, van der Graaf W, Sleijfer D, Suurmeijer A, Van Veldhuisen D: The dilemma of the strive for apoptosis in oncology. Crit Rev Oncol Hematol 2005, 53, 101-113.
 
19.
Davis C, Milner J: Frontiers in nutrigenomics, proteomics, metabolomics and cancer prevention. Mutat Res 2004, 551, 51-64.
 
20.
Milner J: Molecular targets for bioactive food components. J Nutr 2004, 134, 2492-2498.
 
21.
Jacobs LR: Eff ect of dietary fi ber on colonic cell proliferation and its relationship to colon carcinogenesis. Prev Med 1987, 16(4), 566-571.
 
22.
Jacobs LR: Relationship between dietary fi ber and cancer: metabolic, physiologic, and cellular mechanisms. Proc Soc Exp Biol Med 1986, 183(3), 299-310.
 
23.
Jacobs LR: Modifi cation of experimental colon carcinogenesis by dietary fi bers. Adv Exp Med Biol 1986, 206, 105-118.
 
24.
Karunagaran D, Rashmi R, Kumar TR: Induction of apoptosis by curcumin and its implications for cancer therapy. Curr Cancer Drug Targets 2005, 5(2), 117-129.
 
25.
Kim SJ, Hellerstein MK: Pharmacological doses of dietary curcumin increase colon epithelial cell proliferation in vivo in rats. Phytother Res 2007, 21(10), 995-998.
 
26.
Block G, Patterson B, Subar A: Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence. Nutr Cancer 1992, 18, 1-29.
 
27.
Ernst E: Can allium vegetables prevent cancer? Phytomed 1997, 4, 79-83.
 
28.
You WC, Blot WJ, Chang YS, Ershow AG, Yang ZT, An Q, Henderson B, Xu GW, Fraumeni JF, Wang TG: Diet and high risk of stomach cancer in Shandong, China. Cancer Res 1988, 48, 3518-3523.
 
29.
Steinmetz KA, Potter JD: Vegetables, fruit and cancer II. Mechanisms. Cancer Causes Control 1991, 2, 427-442.
 
30.
Reuter HD, Koch HP, Lawson LD: Therapeutic eff ects and applications of garlic and its preparations. In: Garlic. The Science and Therapeutic Application of Allium sativum L. and Related Species, 2nd Ed., Koch HP, Lawson LD (eds.), Williams & Wilkins, Baltimore 1996.
 
31.
Arikawa AY, Gallaher DD: Cruciferous vegetables reduce morphological markers of colon cancer risk in dimethylhydrazine-treated rats. J Nutr 2008, 138(3), 526-32.
 
32.
Michnovicz JJ, Bradlow HL: Altered estrogen metabolism and excretion in humans following consumption of indole carbinol. Nutr Cancer 1991, 16, 59-66.
 
33.
Hasler CM: Functional Foods: Their Role in Disease Prevention and Health Promotion. A Publication of the Institute of Food Technologists. Expert Panel on Food Safety and Nutrition. www. NutriWatch.com.
 
34.
Dashwood RH: Indol-3-carbinol Anticarcinogen or tumor promoter in Brassica vegetables. Chem Biol Ineractions 1998, 1(10), 1-5.
 
35.
Hasegawa S, Miyake M: Biochemistry and biological functions of citrus limonoids. Food Rev Intl 1996, 12, 413-435.
 
36.
Gould MN: Cancer chemoprevention and therapy by monoterpenes. Environ Health Perspec 1997, 105, 977-979.
 
37.
Ripple GH, Gould MN, Stewart JA, Tutsch KD, Arzoomanian RZ, Alberti D, Feierabend C, Pomplun M, Wilding G, Bailey HH: Phase I clinical trial of peillyl alcohol administered daily. Clin Cancer Res 1988, 4, 1159-1164.
 
38.
Godlewski MM, Ślązak P, Zabielski R, Piastowska A, Gralak MA: Quantitative study of soybean-induced changes in proliferation and programmed cell death in the intestinal mucosa of young rats. J Physiol Pharmacol 2006, 57 (Suppl 7), 125-33.
 
39.
Messina M, Barnes S, Setchell KDR: Phytooestrogens and breast cancer. Lancet 1997, 350, 71-972.
 
40.
Thompson LU: Flaxseed, lignans, and cancer. In: Flaxseed in Human Nutrition, (ed). Cunnane S, Thompson LU: AOCS Press, Champaign, IL, 1995, 219-236.
 
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