Assessment of the expression of neutrophil CD11b receptors in preterm infants
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Polish Mothers’ Health Centre Research Institute, Łódź, Poland
Keck School of Medicine, University of Southern California, Los Angeles, USA
Krzysztof Zięba   

Polish Mother’s Health Centre Research Institute, Rzgowska 281/289, 93-338 Łódź, Poland.
J Pre Clin Clin Res. 2009;3(1):54–57
The objective of the study was to assess the neutrophil surface expression of CD11b as a marker of early onset infection in preterm infants. The study comprised 16 pre-term infants with gestational age of 26-32 weeks, suspected of infection within 48 hours of life, and 13 healthy term infants who served as the control. A full sepsis screen was performed in both groups. There was no increase in CD11b expression on neutrophil surface even in infants with elevated CRP. None of the infants had positive blood cultures. The results in this study of pre-term infants born before 33 weeks of gestation showed that there is no increase in neutrophil CD11b expression; however, none of the infants had positive blood cultures. The diagnostic utility of neutrophil CD11b expression in pre-term infants needs to be further evaluated.
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