RESEARCH PAPER
Antistreptokinase antibodies influence Adenosine diphosphate-inducible platelet aggregation
 
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Educational and Scientific Centre “Institute of Biology”, National Taras Shevchenko University, Kiev, Ukraine
CORRESPONDING AUTHOR
Nataliia Burlova-Vasilieva   

National Taras Shevchenko University, Kiev, Educational and Scientific Centre “Institute of Biology”, Volodimirska Street 64, 01601, Kiev, Ukraine.
 
J Pre Clin Clin Res. 2010;4(2):92–95
KEYWORDS
ABSTRACT
The objective of the study was to investigate the effect of streptokinase/antistreptokinase antibodies on Adenosine 5-diphosphate (ADP)-inducible platelet aggregation under steptokinase treatment. ADP-inducible platelet aggregation was determined using light transmission aggregometry (LTA). Baseline rabbits (7) and subjects after intravenous infusion of streptokinase (7) were observed. The presence of antistreptokinase antibodies and plasminogen activators inhibitor type 1 (PAI-1) were determined using ELISA. 7 days after intravenous infusion of streptokinase (Sk) ADP-inducible platelet aggregation in platelet rich plasma (PRP) did not increase baseline level, and was inhibited by Sk in a dose-dependent manner. Sk in a concentration of 16 mkg/ml was associated with significantly reduced ADP-inducible platelet aggregation. Concentration of PAI-1 was significantly elevated in platelet fraction. ADP-inducible platelet aggregation peaked at 7 weeks after intravenous infusion of Sk; Sk-inducible inhibition was not observed. 7 days after administration of Sk ADP-inducible platelet aggregation was normal, although PAI-1 level was elevated in platelet fraction. Platelet aggregation in response to ADP was significantly increased at 7 weeks after Sk administration when compared to baseline level. Inhibition effect of streptokinase on ADP-inducible platelet aggregation was not observed.
 
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