Joint hypermobility in fibromyalgia patients has no impact on tests for disease severity
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The Parker Institute, Frederiksberg Hospital, Capital Region, Denmark
University Library, Copenhagen, Denmark
Søren Ribel-Madsen   

The Parker Institute, Frederiksberg Hospital, Nordre Fasanvej 57, DK-2000 Frederiksberg, Denmark.
J Pre Clin Clin Res. 2008;2(2):122–126
Benign joint hypermobility appears more frequently in fibromyalgia patients than in a comparable healthy cohort. The aim of this study was to investigate if fibromyalgia patients also diagnosed with benign joint hypermobility may be a distinct subgroup in the fibromyalgia population.The presence of benign joint hypermobility was determined in a population of 27 fibromyalgia patients. Relevant anatomical, physiological and biochemical parameters were measured, and specific fibromyalgia criteria were assessed for each patient. 15 patients suffered from benign joint hypermobility. In general, the presence of benign joint hypermobilty did not change the disease appearance in fibromyalgia patients. This applied to the main characteristics – pain (p=0.6), muscle strength (p=0.6), hydroxyproline in skin (p=0.99), or collagen markers in urine CTX-I and CTX-II (p=0.45 and 0.41, respectively) – as well as to other studied variables. The only difference found between the two groups was in concentrations of plasma electrolytes with a higher potassium concentration level and lower sodium to potassium ratio in the hypermobile group (p=0.026), which showed the same mean as seen in the healthy population. Benign joint hypermobility with fibromyalgia does not change the fibromyalgia disease characteristics, and hypermobile fibromyalgia patients do not appear to differ in disease severity from the rest of the fibromyalgia population.
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