Immobilization and experimental periodontitis in tibial anterior muscle of wistar rats
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Universidade Estadual do Oeste do Paraná, Brazil
Gladson Ricardo Flor Bertolini   

Universidade Estadual do Oeste do Paraná, Rua Universitária, 2069., 85819110, Cascavel, Brazil
J Pre Clin Clin Res. 2019;13(1):1–4
Introduction and objective:
Periodontal disease (PD) is a chronic inflammation, locally attacking the supporting tissues of the tooth; this inflammatory condition can affect other systems, such as muscle tissue, which is also susceptible to several types of injury such as caused by immobilization. The aim of this study was to assess whether periodontal disease potentiates the deleterious effects of immobilization of the anterior tibial muscle of Wistar rats.

Material and methods:
Twenty animals were randomly assigned to four groups (n=5): Control Group (CG), Periodontal Disease Group (PDG), Immobilized Group (IG) and PD plus Immobilization Group (PDIG). PD was induced on day 1 of the experiment by placing a cotton thread in the first lower molars for 30 days, favouring the accumulation of bacterial plaque. On day 15, the right pelvic limb was immobilized for 15 days. On day 30, the animals were euthanized and the tibialis anterior muscle was collected with further processing for histomorphometric analysis.

. In the cross-sectional area there were PDIG differences between CG and PDG. For the larger diameter, CG was higher than IG and PDIG. For the smaller diameter, PDIG presented a lower value among all the groups in the same way with the number of nuclei. For connective tissue, there was an increase in the amount between the CG and PDIG, IG and PDIG groups, as well as PDG and PDIG.

Periodontal disease potentiated the deleterious effects of immobilization on the anterior tibialis muscle.

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