Homeostasis of chosen microelements in liver of rats receiving lithium and/or selenium orally
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Chair and Department of Medical Chemistry, Medical University of Lublin, Poland
Chair and Department of Bromatology, Medical University of Lublin, Poland
J Pre Clin Clin Res. 2017;11(2):132–135
Introduction and objective:
Lithium and selenium have been the subjects of extensive research for many years. Concern about the physiological action of these elements results from the application of lithium in medicine, as well as the beneficial influence of selenium supplementation in different pathological states. However, little data are available concerning their effect on the homeostasis of essential microelements in organs. Therefore, the aim of the current study was to evaluate the influence of lithium and/or selenium administration on homeostasis of iron, zinc, copper and manganese in the liver of rats.

Material and methods:
The experiment was carried on 24 male Wistar rats (4 groups of 6 animals) subjected to the treatment with: group I (control) – saline; group II – lithium carbonate at a dose of 2.7 mg Li/kg b.w.; group III – sodium selenite at a dose of 0.5 mg Se/kg b.w.; group IV – both lithium carbonate and sodium selenite at the doses mentioned above. Administration was performed for 6 weeks, once a day by stomach tube, in the form of water solutions.

The tissue content of zinc, iron and manganese showed no statistical differences among the studied groups. Zn was slightly decreased in group III vs. control and group II. Fe was insignificantly enhanced in groups II and IV vs. control. Mn in group IV was slightly increased vs. groups II and III. Cu in group III was significantly decreased vs. group IV and slightly depleted vs. groups I and II.

With the exception of Cu in the Se-treated group, lithium and/or selenium did not affect the studied microelements’ liver homeostasis in a significant way. These results may contribute to the knowledge of essential microelements homeostasis in human organisms undergoing lithium therapy, and/or selenium supplementation.

Małgorzata Kiełczykowska   
Medica University of Lublin, Chodźki 4 a, 20-093 Lublin, Poland
1. Dell’Osso L, Del Grande C, Gesi C, Carmassi C, Musetti L. A new look at an old drug: neuroprotective effects and therapeutic potentials of lithium salts. Neuropsychiatr Dis Treat. 2016; 12: 1687–1703.
2. Zhang X, Aggarwal P, Li X, Oakman C, Wang Z, Rodriguez R. The role of lithium carbonate and lithium citrate in regulating urinary citrate level and preventing nephrolithiasis. Int J Biomed Sci. 2009; 5(3): 215–222.
3. Gitlin M. Lithium side effects and toxicity: prevalence and management strategies. Int J Bipolar Disord. 2016; 4(1): 27.
4. Zyoud SH, Waring WS, Sweileh WM, Al-Jabi SW. Global Research Trends in Lithium Toxicity from 1913 to 2015: A Bibliometric Analysis. Basic Clin Pharmacol Toxicol. 2017; doi/10.1111/bcpt.12755/epdf.
5. South PK, Morris VC, Smith AD, Levander OA. Effect of selenium deficiency on liver iron stores in mice. Nutr Res. 2000; 20(7): 1027–1040.
6. Sivrikaya A, Akil M, Bicer M, Kilic M, Baltaci AK, Mogulkoc R. The effect of selenium supplementation on elements distribution in liver of rats subject to strenuous swimming. Bratisl Lek Listy. 2013; 114(1): 12–14.
7. Erkekoglu P, Arnaud J, Rachidi W, Kocer-Gumusel B, Favier A, Hincal F. The effects of di(2-ethylhexyl) phthalate and/or selenium on trace element levels in different organs of rats. J Trace Elem Med Biol. 2015; 29: 296–302.
8. Nwagha UI, Ogbodo SO, Nwogu-Ikojo EE, Ibegbu DM, Ejezie FE, Nwagha TU, Dim CC. Copper and selenium status of healthy pregnant women in Enugu, southeastern Nigeria. Niger J Clin Pract. 2011; 14(4): 408–412.
9. Vijaimohan K, Mallika J, Shyamala DC. Chemoprotective Effect of Sobatum against Lithium-Induced Oxidative Damage in Rats. J Young Pharm. 2010; 2(1): 68–73.
10. Wrobel JK, Power R, Toborek M. Biological activity of selenium: Revisited. IUBMB Life. 2016; 68(2): 97–105.
11. Doğan S, Yazici H, Yalçinkaya E, Erdoğdu HI, Tokgöz SA, Sarici F, Namuslu M, Sarikaya Y. Protective Effect of Selenium Against Cisplatin- Induced Ototoxicity in an Experimental Design. J Craniofac Surg. 2016; 27(7): e610-e614.
12. ChadhaVD, Bhalla P, Dhawan DK. Zinc modulates lithium-induced hepatotoxicity in rats. Liver Int. 2008; 28(4): 558–565.
13. Kiełczykowska M, Musik I, Kurzepa J, Żelazowska R, Lewandowska A, Paździor M, Kocot J. The Influence of Lithium and/or Selenium Treatment on Homeostasis of Chosen Bioelements in Rats. Biol Trace Elem Res. 2016; 016–0906-x.
14. Herman K. An outline of atomic absorption spectrometry. Based on ANTI UNICAM – atomic absorption spectrometry methods manual. Warsaw, 1991.
15. Milic S, Mikolasevic I, Orlic L, Devcic E, Starcevic-Cizmarevic N, Stimac D, Kapovic M, Ristic S. The Role of Iron and Iron Overload in Chronic Liver Disease. Med Sci Monit. 2016; 22: 2144–2151.
16. Morrell A, Tallino S, Yu L, Burkhead JL. The role of insufficient copper in lipid synthesis and fatty-liver disease. IUBMB Life. 2017; 69(4): 263–270.
17. Konzack A, Jakupovic M, Kubaichuk K, Görlach A, Dombrowski F, Miinalainen I, Sormunen R, Kietzmann T. Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis. Antioxid Redox Signal. 2015; 23(14): 1059–75.
18. Al-Awadi FM, Anim JT, Srikumar TS, Mona Al-Rustom. Possible Role of Trace Elements in the Hypoglycemic Effect of Plants Extract in Diabetic Rats.J Trace Elem Exp Med. 2004; 17: 31–44.
19. Monedero-Prieto MJ, González-Pérez MJ, González-Reimers E, Hernández-Pérez O, Monereo-Muñoz M, Galindo-Martín L, Quintero- Platt G, Abreu-González P. Effects of selenium on liver and muscle contents and urinary excretion of zinc, copper, iron and manganese. Biol Trace Elem Res. 2014; 158(2): 224–229.
20. Yu S, Beynen AC. The lowering effect of high copper intake on selenium retention in weanling rats depends on the selenium concentration of the diet. J Anim Physiol a Anim Nutr. 2001; 85: 29–37.
21. Matsumoto K, Terada S, Ariyoshi M, Okajo A, Hisamatsu A, Ui I, Endo K. The effect of long-running severe selenium-deficiency on the amount of iron and zinc in the organs of rats. Molecules. 2009; 14(11): 4440–4453.
22. Chowdhury MI, Hasan M, Islam MS, Sarwar MS, Amin MN, Uddin SM, Rahaman MZ, Banik S, Hussain MS, Yokota K, Hasnat A. Elevated serum MDA and depleted non-enzymatic antioxidants, macro-minerals and trace elements are associated with bipolar disorder. J Trace Elem Med Biol. 2017; 39: 162–168.
23. Chmielnicka J, Nasiadek M. The trace elements in response to lithium intoxication in renal failure. Ecotoxicol Environ Saf. 2003; 55(2): 178–183.
24. Tandon A, Nagpaul JP, Bandhu H, Singh N, Dhawan DK. Effect of lithium on hepatic and serum elemental status under different dietary protein regimens. Biol Trace Elem Res. 1999; 68(1): 51–62.
25. Dhawan D, Singh A, Singh B, Bandhu HK, Chand B, Singh N. Effect of lithium augmentation on the trace elemental profile in diabetic rats. BioMetals. 1999; 12(4): 375–381.
26. Rich AM, Lajoie TM. Wilson’s disease--treatment of psychiatric manifestations in pregnancy. Psychosomatics. 2012; 53(2): 175–177.
27. Zhao J, Shirley RB, Dibner JJ, Wedekind KJ, Yan F, Fisher P, Hampton TR, Evans JL, Vazquez-Añon M. Superior growth performance in broiler chicks fed chelated compared to inorganic zinc in presence of elevated dietary copper. J Anim Sci Biotechnol. 2016; 7: 13.